Simpsonville Methodist Episcopal Church was formed in 1825 under the leadership of Rev W.B. Kavanaugh, a Methodist Circuit Rider. The first church services were held in homes. Records show a church was built in 1840 on First Street.

Following a fire that ravaged the original building, the present building was completed in 1876 with an approximate cost of $7,500. The memorial stained glass windows were installed in the church sanctuary in 1965. In 1987 this building, with its superb artistry and steeple, was placed on the National Register of Historic places.  

In 1839 the Methodist Episcopal Church became the Methodist Church and our church became Simpsonville Methodist Church. In 1842 the Shelby Circuit was under the ministry of Napoleon Lewis and John Fields.
In 1968, following the merger of the Methodist Church and the Evangelical United Brethren Church the church became Simpsonville United Methodist Church. Due to issues within the United Methodist denomination the church membership voted in 2023 to disaffiliate with the United Methodist Church and become an independent church with the name of Simpsonville Methodist Church. 

Since 1825 our church has been an important part of the Simpsonville community committed to carry out the Great Commission of Jesus as stated in Matthew 28 to go into all the world to make disciples of Christ, teaching and baptizing in His name.